Leukotriene catabolic process

Across TCGA patient cohorts, RNA activity of the Leukotriene catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BPI, SLC25A14, and ARL13B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene catabolic process activity versus BPI in PDAC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BPI →	+0.345	+0.866	.001	<.001	3	3
PDAC	SLC25A14 →	-0.389	-0.624	.001	.004	3	3
PDAC	ARL13B →	-0.222	-0.523	.009	.004	3	3
LSCC	CEACAM3 →	+0.559	+0.110	<.001	.002	3	3
UCEC	CCDC28A →	-1.329	-1.383	.006	<.001	3	3
UCEC	LSG1 →	-1.215	-1.374	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036100 vs BPI — PDAC

Explore this scatter interactively →