Phosphatidylinositol-3-phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol-3-phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7L1, TBC1D2B, and DOCK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol-3-phosphate biosynthetic process activity versus RPL7L1 in BRCA (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL7L1 →	-0.480	-0.046	.001	<.001	3	9
OV	TBC1D2B →	+0.331	+0.063	.001	.001	3	9
GBM	DOCK2 →	+0.524	+0.052	<.001	<.001	3	9
LUAD	DOCK8 →	+0.411	+0.051	<.001	<.001	3	9
HNSC	ELMO1 →	+0.565	+0.065	<.001	.003	3	9
BRCA	IL16 →	+0.722	+0.057	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036092 vs RPL7L1 — BRCA

Explore this scatter interactively →