Phosphatidylinositol-3-phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol-3-phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC12, ERP44, and CEP85, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUC12 grouped by Phosphatidylinositol-3-phosphate biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MUC12 →	-0.215	-0.619	.006	.006	2	5
BLOOD_Leukemia	ERP44 →	-0.489	-0.985	<.001	<.001	3	4
BLOOD_Lymphoma	CEP85 →	-0.697	-1.975	.003	<.001	3	3
CNS	CNIH2 →	-0.923	-0.973	.009	.007	3	3
PANCREAS	FBXO48 →	-0.373	-0.931	<.001	.007	3	3
PANCREAS	EIF2AK2 →	+0.708	+0.925	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUC12 by Phosphatidylinositol-3-phosphate biosynthetic process activity — BREAST

Explore this box plot interactively →