Phosphatidylinositol-3-phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol-3-phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PALM3, TNFAIP1, and MRPL16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol-3-phosphate biosynthetic process activity versus PALM3 in OVARY (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PALM3 →	-1.900	-0.867	.005	.005	3	4
BLOOD_Lymphoma	TNFAIP1 →	-0.513	-1.286	.002	<.001	3	4
BLOOD_Lymphoma	MRPL16 →	+0.577	+1.169	.004	<.001	3	4
CNS	ST6GALNAC4 →	+0.734	+0.585	.004	<.001	2	4
LUNG_SCLC	RASD1 →	+3.474	+0.994	<.001	<.001	3	3
LUNG_SCLC	ERBIN →	-0.926	-0.899	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036092 vs PALM3 — OVARY

Explore this scatter interactively →