Cleavage furrow formation

Across TCGA cell cohorts, RNA activity of the Cleavage furrow formation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND3, PLXNA3, and PRRT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND3 grouped by Cleavage furrow formation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DENND3 →	+0.925	+0.128	.004	.001	3	4
LIVER	PLXNA3 →	+1.346	+0.280	<.001	<.001	3	4
LIVER	PRRT3 →	+0.586	+0.296	.001	<.001	3	4
LIVER	F8A1 →	+1.494	+0.277	.008	.005	3	4
LARGE_INTESTINE	TMCO3 →	-0.608	-0.160	.008	.004	3	3
LARGE_INTESTINE	MRPS17 →	+0.361	+0.154	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND3 by Cleavage furrow formation activity — BREAST

Explore this box plot interactively →