Replacement ossification

Across TCGA patient cohorts, RNA activity of the Replacement ossification pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECM2, CCN4, and CARMN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replacement ossification activity versus ECM2 in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ECM2 →	+0.633	+0.534	.003	.004	3	5
HNSC	CCN4 →	+0.626	+0.498	.002	.001	3	5
UCEC	CARMN →	+1.135	+0.815	.002	.005	3	5
OV	DACT1 →	+0.827	+0.625	.008	.002	3	5
COAD	TRPS1 →	+0.453	+0.478	.001	.002	3	4
COAD	CALD1 →	+0.662	+0.732	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036075 vs ECM2 — HNSC

Explore this scatter interactively →