Replacement ossification

Across TCGA cell cohorts, RNA activity of the Replacement ossification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1L, AVEN, and PLEKHG4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replacement ossification activity versus GPD1L in BLOOD_Leukemia (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPD1L →	-1.228	-0.349	.007	<.001	3	2
BLOOD_Myeloma	AVEN →	-1.250	-1.675	.003	<.001	3	2
BLOOD_Myeloma	PLEKHG4 →	+3.114	+1.620	.003	<.001	3	2
BONE	CDC25B →	-0.783	-1.690	<.001	<.001	3	2
BONE	IDH3B →	-1.276	-1.690	.006	<.001	3	2
BONE	HSD17B1 →	-1.150	-1.690	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036075 vs GPD1L — BLOOD_Leukemia

Explore this scatter interactively →