Fucosylation

pathway activity — cross-omics
GO:0036065Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Fucosylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK1, CC2D1A, and EXPH5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCMPK1 →+0.418+0.076<.001<.00135
UCECCC2D1A →+0.169+0.050<.001.00834
UCECEXPH5 →+0.327+0.062.009.00625
PDACPLS1 →+0.566+0.073<.001<.00134
BRCACOMT →+0.379+0.029.009.00334
HNSCCD5 →-0.428-0.052<.001.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration