Fucosylation

pathway activity — cross-omics
GO:0036065Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Fucosylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YAP1_S289, SPHK2_S414, and TCOF1_S1257, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVYAP1_S289 →+0.695+0.159<.001.00133
BRCASPHK2_S414 →+1.363+0.178.002<.00133
OVTCOF1_S1257 →-1.085-0.231.001<.00133
OVCDC42EP4_S309 →-1.430-0.578<.001<.00133
OVCRTC3_S396 →+0.880+0.261<.001<.00133
UCECEP300_T1909 →-0.896-0.378<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration