"CD8-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP1, CRLF3, and RAD51, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "CD8-positive, alpha-beta T cell activation" activity versus PARP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PARP1 →	+1.374	+0.474	<.001	.003	3	6
OVARY	CRLF3 →	+0.630	+0.365	.007	.006	3	6
LIVER	RAD51 →	+0.776	+0.351	.009	<.001	3	6
LIVER	DNAJC11 →	+0.768	+0.352	<.001	<.001	3	5
BLOOD_Myeloma	BCL7A →	+1.924	+0.236	.002	.001	3	5
OVARY	NFIC →	+1.931	+0.367	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036037 vs PARP1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →