Response to interleukin-3

Across TCGA cell cohorts, RNA activity of the Response to interleukin-3 pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS25, RPL21, and SLC35E3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS25 grouped by Response to interleukin-3-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPS25 →	+0.993	+1.059	.008	.009	3	4
UPPER_AERODIGESTIVE_TRACT	RPL21 →	+1.361	+1.204	<.001	.008	3	4
BLOOD_Myeloma	SLC35E3 →	+1.607	+2.359	<.001	<.001	3	4
CNS	GBP1 →	-1.540	-1.193	.001	<.001	3	4
SOFT_TISSUE	VEGFA →	+2.565	+1.343	.001	.006	3	3
SOFT_TISSUE	NCBP1 →	-0.567	-1.159	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS25 by Response to interleukin-3 activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →