Response to interleukin-3

Across TCGA cell cohorts, RNA activity of the Response to interleukin-3 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRAP, LAG3, and MSH2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-3 activity versus BRAP in BLOOD_Leukemia (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRAP →	+0.334	+0.138	.002	.004	1	1
BLOOD_Leukemia	LAG3 →	+0.499	+0.138	.008	.004	1	1
BLOOD_Leukemia	MSH2 →	+0.705	+0.138	.003	.004	1	1
BLOOD_Leukemia	TBC1D2 →	-0.819	-0.138	.007	.004	1	1
BLOOD_Leukemia	TLL2 →	+0.065	+0.138	.005	.004	1	1
BLOOD_Leukemia	EFNA2 →	+0.075	+0.138	.004	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036015 vs BRAP — BLOOD_Leukemia

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