Response to interleukin-3

Across TCGA cell cohorts, RNA activity of the Response to interleukin-3 pathway is significantly associated with the total protein of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are eIF4G, FOXO3a, and IGFBP2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-3 activity versus eIF4G in BLOOD_Leukemia (Pearson r = 0.94).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	eIF4G →	+2.042	+0.138	.044	.004	1	1
BLOOD_Leukemia	FOXO3a →	+0.499	+0.138	.031	.004	1	1
BLOOD_Leukemia	IGFBP2 →	+0.894	+0.138	.025	.004	1	1
BLOOD_Leukemia	Paxillin →	+1.273	+0.138	.015	.004	1	1
BLOOD_Leukemia	Porin →	-0.505	-0.138	.007	.004	1	1
BLOOD_Leukemia	Rictor →	+0.446	+0.138	.005	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036015 vs eIF4G — BLOOD_Leukemia

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