Protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to endosome pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4C, CBFA2T3, and CILK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP4C grouped by Protein localization to endosome-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPP4C →	-0.323	-0.151	.003	.007	3	5
OVARY	CBFA2T3 →	+0.141	+0.110	.003	.003	3	5
URINARY_TRACT	CILK1 →	+0.347	+0.141	.007	.003	3	4
BONE	PLRG1 →	-0.484	-0.193	<.001	.003	3	4
BLOOD_Leukemia	RAD54L2 →	+0.261	+0.127	.001	<.001	3	4
LIVER	PRKCI →	+0.171	+0.176	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP4C by Protein localization to endosome activity — LIVER

Explore this box plot interactively →