Protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to endosome pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASHC2C, WASHC2A, and CSGALNACT2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endosome activity versus WASHC2C in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WASHC2C →	+1.030	+0.193	<.001	<.001	3	20
BONE	WASHC2A →	+1.056	+0.242	<.001	<.001	3	19
BONE	CSGALNACT2 →	+1.162	+0.250	<.001	<.001	3	17
CNS	GNA12 →	+1.280	+0.139	<.001	<.001	3	16
URINARY_TRACT	NLGN2 →	+1.511	+0.123	<.001	<.001	3	16
LIVER	DAPK3 →	+1.193	+0.181	.004	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036010 vs WASHC2C — LIVER

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