Protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to endosome pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKN2, CLN6, and ATAT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKN2 grouped by Protein localization to endosome-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PKN2 →	+0.172	+0.285	<.001	<.001	3	3
SKIN	CLN6 →	-0.252	-0.357	.009	<.001	3	3
STOMACH	ATAT1 →	-0.401	-0.424	.003	.002	3	3
CNS	ST14 →	-0.436	-0.376	.001	.001	3	3
BLOOD_Leukemia	PLSCR2 →	+0.135	+0.281	.007	.001	3	3
OVARY	ARL8B →	-0.188	-0.382	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKN2 by Protein localization to endosome activity — SKIN

Explore this box plot interactively →