Protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to endosome pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB5A, CLTC, and ARF6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endosome activity versus RAB5A in STOMACH (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RAB5A →	+1.392	+0.399	<.001	<.001	3	10
URINARY_TRACT	CLTC →	+0.972	+1.706	.001	.001	3	10
PANCREAS	ARF6 →	+1.320	+0.394	<.001	.009	3	9
SKIN	ARL8B →	+0.447	+0.374	.005	.001	3	9
URINARY_TRACT	TOLLIP →	+1.039	+1.696	.005	.001	3	8
BONE	ARPC4 →	+0.708	+0.538	.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036010 vs RAB5A — STOMACH

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