Tetrahydrofolate interconversion

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate interconversion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, POU6F2-AS1, and MRPS9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate interconversion activity versus GJA1 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GJA1 →	-0.814	-0.259	<.001	.008	3	3
GBM	POU6F2-AS1 →	-0.400	-0.139	.008	.001	3	3
COAD	MRPS9 →	+0.216	+0.096	.002	.005	3	2
GBM	RN7SKP232 →	+0.164	+0.117	.001	.006	3	2
COAD	MAGI1-AS1 →	-0.160	-0.120	.004	.003	3	2
COAD	CCL23 →	-0.495	-0.137	.003	.003	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035999 vs GJA1 — CCRCC

Explore this scatter interactively →