Tetrahydrofolate interconversion

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate interconversion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPNMB, ZNF319, and CRY1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPNMB grouped by Tetrahydrofolate interconversion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPNMB →	-1.989	-1.186	.003	.002	3	5
BONE	ZNF319 →	-0.700	-2.051	.004	<.001	3	4
LIVER	CRY1 →	-0.799	-1.194	.005	.004	3	4
LUNG_SCLC	PRKRIP1 →	-0.549	-0.912	<.001	.006	3	4
LUNG_SCLC	CLUH →	+0.680	+1.085	.007	<.001	3	4
LUNG_SCLC	DLK2 →	-1.633	-1.057	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPNMB by Tetrahydrofolate interconversion activity — STOMACH

Explore this box plot interactively →