Detection of muscle stretch

Across TCGA patient cohorts, RNA activity of the Detection of muscle stretch pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK2, CYC1, and YTHDF3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of muscle stretch activity versus PTK2 in BRCA (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTK2 →	+0.422	+0.112	<.001	<.001	3	7
LSCC	CYC1 →	+0.213	+0.054	.002	.001	3	6
COAD	YTHDF3 →	+0.334	+0.112	<.001	<.001	3	5
LSCC	SCRIB →	+0.367	+0.101	<.001	<.001	3	5
BRCA	HGH1 →	+0.227	+0.065	<.001	<.001	3	5
COAD	PUF60 →	+0.287	+0.098	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035995 vs PTK2 — BRCA

Explore this scatter interactively →