Detection of muscle stretch

Across TCGA patient cohorts, RNA activity of the Detection of muscle stretch pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ING2, IMPG2, and AKAP6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of muscle stretch activity versus ING2 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ING2 →	+0.452	+0.158	<.001	.003	3	3
BRCA	IMPG2 →	+0.174	+0.121	.008	.002	3	3
HNSC	AKAP6 →	+0.790	+2.341	.002	.003	3	3
GBM	JAKMIP1 →	-0.194	-0.128	.003	.001	3	3
GBM	PLCL2 →	-0.388	-0.137	<.001	<.001	3	3
GBM	MTMR1 →	-0.216	-0.126	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035995 vs ING2 — BRCA

Explore this scatter interactively →