Detection of muscle stretch

Across TCGA cell cohorts, RNA activity of the Detection of muscle stretch pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD61, EHD1, and NAA40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of muscle stretch activity versus ANKRD61 in LUNG_NSCLC_LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANKRD61 →	+0.271	+0.479	.004	.009	3	4
PANCREAS	EHD1 →	+1.184	+0.288	.007	.001	3	4
PANCREAS	NAA40 →	+0.547	+0.205	.004	.004	3	4
PANCREAS	RNF26 →	+0.965	+0.307	.002	<.001	3	3
LUNG_NSCLC_LUAD	PTK2 →	+0.598	+0.624	.002	.006	2	4
KIDNEY	KCTD1 →	+1.720	+0.174	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035995 vs ANKRD61 — LUNG_NSCLC_LUAD

Explore this scatter interactively →