Response to muscle stretch

Across TCGA patient cohorts, RNA activity of the Response to muscle stretch pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA25, TLN1_S2040, and CALD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle stretch activity versus NAA25 in LUAD (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAA25 →	-0.386	-0.056	<.001	<.001	3	7
UCEC	TLN1_S2040 →	+0.885	+0.091	.001	<.001	3	7
UCEC	CALD1 →	+0.877	+0.076	<.001	<.001	3	7
CCRCC	CNN1 →	+1.145	+0.052	<.001	<.001	3	7
HNSC	DMD →	+1.150	+0.078	<.001	<.001	3	7
UCEC	LIMS1 →	+0.468	+0.100	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035994 vs NAA25 — LUAD

Explore this scatter interactively →