Response to muscle stretch

Across TCGA cell cohorts, RNA activity of the Response to muscle stretch pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARFGAP1, ZNF528, and ZMYM6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARFGAP1 grouped by Response to muscle stretch-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARFGAP1 →	-0.638	-0.601	.009	.007	3	6
SOFT_TISSUE	ZNF528 →	-2.523	-1.406	.001	.008	3	6
LUNG_NSCLC_LUAD	ZMYM6 →	-0.461	-0.952	.001	<.001	3	5
BREAST	MTPN →	-0.767	-0.766	.001	.002	3	5
BLOOD_Leukemia	CNRIP1 →	-3.760	-1.278	.007	.002	3	4
STOMACH	ZNF483 →	-1.065	-1.108	.002	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARFGAP1 by Response to muscle stretch activity — LARGE_INTESTINE

Explore this box plot interactively →