Response to muscle stretch

Across TCGA cell cohorts, RNA activity of the Response to muscle stretch pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, ARRDC1, and SERPINB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle stretch activity versus GSN in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSN →	+2.457	+0.193	.003	.002	2	7
BLOOD_Leukemia	ARRDC1 →	+1.064	+0.237	.001	<.001	2	5
BLOOD_Leukemia	SERPINB1 →	+3.099	+0.238	<.001	<.001	3	4
BLOOD_Leukemia	SLC66A1 →	+1.584	+0.290	<.001	<.001	3	4
LIVER	DIRAS1 →	+1.779	+0.235	.002	.001	3	4
BLOOD_Leukemia	LYST →	+3.454	+0.268	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035994 vs GSN — BLOOD_Leukemia

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