Chondrocyte proliferation

Across TCGA cell cohorts, RNA activity of the Chondrocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC2, LAG3, and IPO4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AOC2 grouped by Chondrocyte proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AOC2 →	+0.194	+0.174	<.001	.001	3	4
SKIN	LAG3 →	+0.226	+0.181	<.001	<.001	3	3
LUNG_NSCLC_LUSC	IPO4 →	+0.414	+1.305	.003	.004	3	3
BLOOD_Lymphoma	PTPN14 →	+0.257	+0.158	.006	.005	3	3
BLOOD_Myeloma	VPS26A →	+0.221	+1.603	.003	<.001	3	3
BLOOD_Myeloma	SHBG →	-0.290	-1.785	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AOC2 by Chondrocyte proliferation activity — SKIN

Explore this box plot interactively →