Endodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Endodermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P3H3, COL5A2, and PLOD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell differentiation activity versus P3H3 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	P3H3 →	+0.669	+0.278	<.001	<.001	3	6
COAD	COL5A2 →	+0.669	+0.225	<.001	.001	3	5
LUAD	PLOD2 →	+0.804	+0.214	<.001	<.001	3	5
UCEC	EIF2AK4_T667 →	+0.441	+0.305	<.001	.001	3	5
LUAD	USP24_S1285 →	-0.888	-0.266	<.001	<.001	3	4
LSCC	FOXO3_S253 →	-0.543	-0.217	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035987 vs P3H3 — GBM

Explore this scatter interactively →