Endodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Endodermal cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGPS2, ZNF652, and TLN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RALGPS2 grouped by Endodermal cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RALGPS2 →	-0.183	-0.120	.004	.004	3	6
LUNG_NSCLC_LUAD	ZNF652 →	-0.152	-0.106	.002	.002	3	5
STOMACH	TLN1 →	+0.434	+0.164	.002	.007	3	5
LUNG_SCLC	THBS4 →	+0.114	+0.202	.004	.001	3	5
LUNG_NSCLC_LUAD	IMP4 →	+0.187	+0.085	.003	.004	3	4
LUNG_SCLC	CRKL →	+0.231	+0.189	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RALGPS2 by Endodermal cell differentiation activity — SKIN

Explore this box plot interactively →