Endodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Endodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECHS1, DSE, and CALD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell differentiation activity versus ECHS1 in LIVER (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ECHS1 →	-0.592	-0.412	.001	<.001	3	5
CNS	DSE →	+1.709	+0.334	<.001	.001	2	6
CNS	CALD1 →	+1.743	+0.487	<.001	<.001	3	5
CNS	MRPL12 →	-0.724	-0.585	<.001	.005	3	5
BONE	NBEAL2 →	-2.702	-0.577	.001	.002	3	4
BONE	ITGA1 →	+2.935	+0.634	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035987 vs ECHS1 — LIVER

Explore this scatter interactively →