Endodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Endodermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FASN, FN1, and AHCY, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell differentiation activity versus FASN in URINARY_TRACT (Pearson r = -0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FASN →	-1.892	-0.376	<.001	.001	3	8
BONE	FN1 →	+2.676	+0.299	<.001	<.001	3	8
URINARY_TRACT	AHCY →	-2.325	-0.353	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	LTA4H →	-1.438	-0.417	<.001	.001	3	7
BONE	SUN2 →	+1.530	+0.354	<.001	<.001	3	7
STOMACH	LAMC1 →	+2.692	+0.264	.007	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035987 vs FASN — URINARY_TRACT

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