Aggrephagy

Across TCGA patient cohorts, RNA activity of the Aggrephagy pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB8, AMZ2, and ATP6V0E1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggrephagy activity versus HSPB8 in GBM (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSPB8 →	+1.557	+0.321	<.001	<.001	3	5
BRCA	AMZ2 →	+0.585	+0.238	<.001	.006	3	5
LUAD	ATP6V0E1 →	+0.441	+0.246	<.001	<.001	3	5
LUAD	SQSTM1 →	+0.651	+0.227	<.001	<.001	3	5
HNSC	STX4 →	+0.331	+0.162	.009	.001	3	5
GBM	P2RX4 →	+0.277	+0.154	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035973 vs HSPB8 — GBM

Explore this scatter interactively →