Aggrephagy

Across TCGA cell cohorts, RNA activity of the Aggrephagy pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXD1, SRPX, and ITGB5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXD1 grouped by Aggrephagy-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOXD1 →	-1.597	-1.030	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SRPX →	-2.015	-1.453	.005	.004	3	4
UPPER_AERODIGESTIVE_TRACT	ITGB5 →	-1.702	-1.850	.003	<.001	3	4
BONE	MAPRE3 →	-2.045	-1.543	<.001	.009	3	4
BREAST	CCNDBP1 →	+1.387	+0.993	.004	.002	3	4
LUNG_SCLC	R3HCC1 →	+0.797	+1.469	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXD1 by Aggrephagy activity — LARGE_INTESTINE

Explore this box plot interactively →