Aggrephagy

Across TCGA cell cohorts, RNA activity of the Aggrephagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, SLC46A3, and ERLEC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggrephagy activity versus SQSTM1 in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SQSTM1 →	+1.940	+0.762	.001	.004	3	5
LIVER	SLC46A3 →	+1.857	+0.496	.006	.006	3	4
SKIN	ERLEC1 →	+0.645	+0.939	.004	.009	3	4
OVARY	CAST →	+1.721	+1.068	<.001	.003	2	4
OVARY	PLEKHF1 →	+1.529	+0.802	.003	.006	2	4
OVARY	LUC7L →	-1.097	-0.991	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035973 vs SQSTM1 — BLOOD_Lymphoma

Explore this scatter interactively →