Peptidyl-threonine dephosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAD2B, SYNJ1, and ZEB2, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine dephosphorylation activity versus ATAD2B in CHOL (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	ATAD2B →	+0.864	+0.049	<.001	<.001	3	31
CHOL	SYNJ1 →	+1.348	+0.064	<.001	<.001	3	31
SCLC	ZEB2 →	+1.812	+0.130	<.001	<.001	3	31
CHOL	CSRNP2 →	+0.924	+0.054	.001	<.001	3	30
MESO	SNRK →	+0.850	+0.043	<.001	.001	3	30
CHOL	CDK17 →	+1.153	+0.056	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035970 vs ATAD2B — CHOL

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