Peptidyl-threonine dephosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYRIA, CLPX, and SHANK3_S1413, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine dephosphorylation activity versus CYRIA in LSCC (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYRIA →	+0.299	+0.049	<.001	<.001	3	8
LUAD	CLPX →	-0.270	-0.029	.004	.004	3	8
OV	SHANK3_S1413 →	+1.127	+0.092	.008	.002	3	6
GBM	TMOD2 →	+0.572	+0.064	<.001	.001	3	6
LUAD	TPI1_S80 →	-0.621	-0.036	.003	.002	3	6
OV	WIPF1 →	+0.365	+0.027	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035970 vs CYRIA — LSCC

Explore this scatter interactively →