Peptidyl-threonine dephosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, MAGI2-AS3, and ARHGAP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine dephosphorylation activity versus LMOD1 in UCEC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.116	+0.178	<.001	<.001	3	5
UCEC	MAGI2-AS3 →	+0.698	+0.127	<.001	.001	3	5
UCEC	ARHGAP6 →	+0.665	+0.121	<.001	.003	3	5
BRCA	HACD4 →	+0.720	+0.107	<.001	.009	3	5
PDAC	KCNK6 →	+0.448	+0.099	<.001	.001	3	5
UCEC	TLE4 →	+0.519	+0.135	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035970 vs LMOD1 — UCEC

Explore this scatter interactively →