Peptidyl-threonine dephosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2CA, PPM1D, and PPP5C, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2CA grouped by Peptidyl-threonine dephosphorylation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP2CA →	-0.805	-1.465	<.001	<.001	3	14
BLOOD_Leukemia	PPM1D →	-0.272	-1.033	.005	.005	3	6
LARGE_INTESTINE	PPP5C →	-0.235	-0.958	.001	.004	3	5
OVARY	MDM2 →	-0.320	-1.323	<.001	<.001	3	5
KIDNEY	PRSS42P →	-0.244	-1.031	.001	.001	3	4
LARGE_INTESTINE	METAP2 →	-0.219	-1.074	.003	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2CA by Peptidyl-threonine dephosphorylation activity — BLOOD_Leukemia

Explore this box plot interactively →