Peptidyl-threonine dephosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFAS, PEBP1, and LOXL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFAS grouped by Peptidyl-threonine dephosphorylation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFAS →	+0.702	+1.030	.001	.002	3	5
LIVER	PEBP1 →	+1.375	+1.751	.004	<.001	3	5
LIVER	LOXL1 →	-2.773	-1.116	.004	.001	3	4
LARGE_INTESTINE	IFT46 →	-0.879	-1.202	<.001	<.001	3	4
LIVER	HAL →	+2.018	+1.087	.007	.002	3	4
OVARY	TFPT →	-0.813	-0.962	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFAS by Peptidyl-threonine dephosphorylation activity — LARGE_INTESTINE

Explore this box plot interactively →