Peptidyl-threonine dephosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-threonine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX33, DPP9, and RBM22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine dephosphorylation activity versus DHX33 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DHX33 →	+0.841	+1.308	.004	.002	3	5
LUNG_NSCLC_LUAD	DPP9 →	+0.867	+0.821	.004	.001	3	5
OVARY	RBM22 →	+0.629	+0.725	.001	.006	3	5
BREAST	PSIP1 →	+1.326	+0.746	<.001	.005	3	5
BREAST	CBL →	+1.197	+1.107	<.001	<.001	3	5
BLOOD_Lymphoma	HTRA2 →	+0.953	+0.450	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035970 vs DHX33 — STOMACH

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