Response to topologically incorrect protein

Across TCGA patient cohorts, RNA activity of the Response to topologically incorrect protein pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPAGT1, ARHGEF11, and TRIM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to topologically incorrect protein activity versus DPAGT1 in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPAGT1 →	-0.735	-0.251	.001	<.001	3	4
CCRCC	ARHGEF11 →	-0.209	-0.087	.002	.006	3	4
HNSC	TRIM3 →	-0.529	-0.174	<.001	<.001	3	3
HNSC	ARHGEF17 →	-0.507	-0.115	.002	.004	3	3
HNSC	MADD →	-0.506	-0.138	.001	.005	3	3
HNSC	ILK →	-0.362	-0.163	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035966 vs DPAGT1 — UCEC

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