Response to topologically incorrect protein

Across TCGA cell cohorts, RNA activity of the Response to topologically incorrect protein pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRF2, RAB5B, and ASH2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRF2 grouped by Response to topologically incorrect protein-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BRF2 →	+0.886	+0.175	<.001	<.001	3	4
LARGE_INTESTINE	RAB5B →	+0.681	+0.152	.002	.001	3	4
LARGE_INTESTINE	ASH2L →	+0.589	+0.099	.002	.004	3	4
LARGE_INTESTINE	ZNF319 →	+0.675	+0.156	.007	.002	3	4
STOMACH	FTO →	+0.702	+0.131	.001	.001	3	4
LUNG_NSCLC_LUSC	TTLL1 →	+0.926	+0.184	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRF2 by Response to topologically incorrect protein activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →