Cardiolipin acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Cardiolipin acyl-chain remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZCCHC24, CDH11, and EPCAM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin acyl-chain remodeling activity versus ZCCHC24 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZCCHC24 →	-0.496	-0.082	<.001	<.001	3	7
BRCA	CDH11 →	-0.449	-0.040	.006	.006	2	7
HNSC	EPCAM →	+1.148	+0.082	<.001	.001	3	6
BRCA	TLN2_T1843 →	-0.500	-0.036	.001	.003	3	6
COAD	TGOLN2_S351 →	-0.608	-0.037	.006	.001	2	6
LSCC	TBC1D2B →	-0.307	-0.084	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035965 vs ZCCHC24 — LSCC

Explore this scatter interactively →