Cardiolipin acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Cardiolipin acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC14, CCNB2P1, and CREBL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin acyl-chain remodeling activity versus TTC14 in PDAC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TTC14 →	-0.366	-0.106	.002	.003	3	4
BRCA	CCNB2P1 →	+0.361	+0.124	<.001	.001	3	4
BRCA	CREBL2 →	-0.473	-0.105	.006	.006	3	4
BRCA	ILKAP →	+0.402	+0.156	<.001	<.001	3	4
PDAC	ZNF451 →	-0.228	-0.089	.006	.004	3	3
PDAC	NEK11 →	-0.347	-0.099	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035965 vs TTC14 — PDAC

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