Cardiolipin acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Cardiolipin acyl-chain remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCLAT1, SMPD4, and RUSF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin acyl-chain remodeling activity versus LCLAT1 in PDAC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LCLAT1 →	+0.556	+0.146	<.001	<.001	2	8
PDAC	SMPD4 →	+0.361	+0.099	<.001	.003	3	4
PDAC	RUSF1 →	+0.453	+0.147	<.001	<.001	3	3
LUAD	XRCC1_S485 →	-0.880	-0.307	<.001	<.001	3	3
UCEC	EPCAM →	+0.590	+0.187	<.001	<.001	3	3
PDAC	FLNC_S954 →	-0.683	-0.098	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035965 vs LCLAT1 — PDAC

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