Cardiolipin acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Cardiolipin acyl-chain remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G6, HADHA, and LCLAT1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G6 grouped by Cardiolipin acyl-chain remodeling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PLA2G6 →	-0.414	-1.186	.004	.008	3	13
LUNG_SCLC	HADHA →	-0.275	-1.548	<.001	<.001	3	13
BREAST	LCLAT1 →	-0.395	-0.927	<.001	<.001	3	8
LARGE_INTESTINE	THEM5 →	-0.240	-1.591	.004	.001	3	6
SOFT_TISSUE	PLA2G5 →	-0.235	-1.614	.002	<.001	3	5
CNS	SOX14 →	-0.223	-1.176	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G6 by Cardiolipin acyl-chain remodeling activity — CNS

Explore this box plot interactively →