Cardiolipin acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Cardiolipin acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G6, PAN2, and ZNF692, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin acyl-chain remodeling activity versus PLA2G6 in SKIN (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PLA2G6 →	+1.938	+0.154	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	PAN2 →	+1.111	+0.082	<.001	.003	3	13
STOMACH	ZNF692 →	+0.809	+0.101	.003	<.001	3	10
KIDNEY	ZNF397 →	+1.196	+0.110	<.001	.002	3	10
LARGE_INTESTINE	NEK5 →	+0.668	+0.088	<.001	.002	3	10
LUNG_NSCLC_LUSC	ACTB →	-1.804	-0.245	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035965 vs PLA2G6 — SKIN

Explore this scatter interactively →