COPI-coated vesicle budding

Across TCGA patient cohorts, RNA activity of the COPI-coated vesicle budding pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NPY1R_S368, TTI1, and PCDH7_S1011, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPI-coated vesicle budding activity versus NPY1R_S368 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NPY1R_S368 →	+1.588	+0.031	.004	.004	3	5
LSCC	TTI1 →	-0.297	-0.047	<.001	<.001	3	4
GBM	PCDH7_S1011 →	+0.608	+0.026	.001	.006	3	4
LSCC	LIN54_S635 →	-0.505	-0.037	<.001	.001	3	4
OV	POLD1 →	-0.402	-0.050	.001	<.001	3	4
UCEC	MACROH2A2 →	+0.501	+0.058	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035964 vs NPY1R_S368 — BRCA

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