COPI-coated vesicle budding

Across TCGA patient cohorts, RNA activity of the COPI-coated vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMCR5, EPS15L1, and PRC1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPI-coated vesicle budding activity versus SMCR5 in LSCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMCR5 →	-0.468	-0.167	<.001	.001	3	4
LSCC	EPS15L1 →	-0.632	-0.183	<.001	<.001	3	4
LSCC	PRC1-AS1 →	-0.350	-0.135	<.001	<.001	3	4
BRCA	SP2 →	-0.271	-0.233	.008	<.001	3	4
UCEC	MSH5 →	-0.750	-0.169	.004	.001	3	4
OV	VEPH1 →	+0.518	+0.200	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035964 vs SMCR5 — LSCC

Explore this scatter interactively →