COPI-coated vesicle budding

Across TCGA cell cohorts, RNA activity of the COPI-coated vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT4, RCN3, and ELK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FUT4 grouped by COPI-coated vesicle budding-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FUT4 →	+1.391	+1.219	<.001	.008	3	5
BLOOD_Leukemia	RCN3 →	+1.678	+1.115	<.001	.002	2	5
BONE	ELK4 →	+0.463	+0.533	.004	<.001	3	4
BLOOD_Leukemia	ARID5B →	-1.718	-1.341	<.001	<.001	3	3
BLOOD_Leukemia	TSPAN32 →	+3.672	+1.537	<.001	<.001	3	3
OVARY	TOP3B →	-0.844	-0.902	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FUT4 by COPI-coated vesicle budding activity — PANCREAS

Explore this box plot interactively →