COPI-coated vesicle budding

Across TCGA cell cohorts, RNA activity of the COPI-coated vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM265, RPL15, and CCT4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPI-coated vesicle budding activity versus TMEM265 in URINARY_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEM265 →	+3.080	+0.381	.003	<.001	3	9
PANCREAS	RPL15 →	-0.964	-0.219	.002	.005	3	8
PANCREAS	CCT4 →	-0.794	-0.235	.002	<.001	3	8
BREAST	POLR1E →	-1.099	-0.137	<.001	<.001	3	7
LARGE_INTESTINE	MYG1 →	-0.415	-0.170	.005	.003	3	7
LARGE_INTESTINE	OVOL1 →	+1.637	+0.204	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035964 vs TMEM265 — URINARY_TRACT

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